Blogpost 053 – DNA Connexions Lyme Panel – A Review of the Facts

Dear friends of Centers for Healing,

After dedicating the past couple of posts to explaining various aspects of the Lyme panel offered by DNA Connexions, I thought it would be good to review the pertinent facts in a single post.

  • Borrelia burgdorferi is the most common cause of Lyme disease in the United States. It is transmitted to humans, and other mammals, by the bite of infected deer ticks.
  • The DNA Connexions Lyme panel is a polymerase chain reaction (i.e., PCR) test, aimed at DNA detection. That is, it is designed to detect the DNA of the causative organism (i.e., B. burgdorferi) of Lyme infection, not the eventual immune response, measured by the production of antibodies, by a given patient suspected of having contracted an active Lyme infection.
  • PCR technology allows the lab to amplify both patient and foreign microbial DNA at the molecular level. This yields exceedingly sensitive and specific results.
  • The panel detects three of the most prevalent Borrelia species, as well as eight common co-infectors (i.e., other tick-transmitted microorganisms). This is significant, since testing for Lyme co-infectors indicates likely infection by the Lyme spirochete as well.
  • This test is a highly sensitive one. It detects between 1 and 10 microbes. We use urine sampling instead of blood, since urine involves a less invasive collection method. This is particularly important when dealing with children.
  • Lyme disease is a multi-stagemulti-system, and multi-organ infection. A positive PCR result indicates the presence of the DNA of B. burgdorferi. However, it does not thereby prove the presence of an active Lyme infection. Meanwhile, a negative result, with its indication of the absence of detectable DNA of B. burgdorferi, does not necessarily prove the absence of an active Lyme infection.
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The DNA Connexions Lyme panel, with its targeted genetic testing, is offered to healthcare professionals as a diagnostic tool for helping them get to the root of Lyme disease. Working together with them, we hope to improve the lives of their patients.

Again, if you would like more information, please visit the lab’s website:


Or, give Amanda a call at the lab: (888) 843-5832. She’ll be happy to answer all your questions.

All the best,

Dr. Blanche Grube
Dr. Blanche Grube with Anita Tibau

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